The table below has a list of the top 100 inventors who have the most US patents. The numbers are based on patent filing between Jan 1981 and May 2021 at the USPTO.
| Inventor | Number of Filings |
| Yamazaki Shunpei | 6819 |
| Silverbrook Kia | 5877 |
| Luo Tao | 3930 |
| Gaal Peter | 3583 |
| Chen Wanshi | 3571 |
| Wood Lowell L. | 3212 |
| Hyde Roderick A. | 3158 |
| Karczewicz Marta | 2925 |
| Wood William I. | 2869 |
| Cheng Kangguo | 2810 |
| Shelton Frederick E. | 2747 |
| Li Junyi | 2527 |
| Gurney Austin L. | 2395 |
| Weder Donald E. | 2387 |
| Goddard Audrey | 2356 |
| Xu Hao | 2148 |
| Ive Jonathan P. | 2104 |
| Wang Wei | 2059 |
| Tegreene Clarence T. | 2046 |
| Zhang Wei | 2009 |
| Zhang Lei | 2006 |
| Wang Lei | 1989 |
| Godowski Paul J. | 1879 |
| Zhang Li | 1858 |
| Walker Jay S. | 1856 |
| Yu Chen-Hua | 1845 |
| Li Li | 1824 |
| Jung Edward K.y. | 1787 |
| Rosen Craig A. | 1774 |
| Ruben Steven M. | 1755 |
| Ji Tingfang | 1747 |
| Andre Bartley K. | 1734 |
| Chen Wei | 1733 |
| Zhang Xiaoxia | 1716 |
| Wang Jun | 1712 |
| Owner Patent | 1698 |
| Malamud Mark A. | 1692 |
| Li Wei | 1691 |
| Levien Royce A. | 1671 |
| Kerr Duncan Robert | 1641 |
| Stringer Christopher J. | 1637 |
| Lord Robert W. | 1631 |
| Kare Jordin T. | 1620 |
| Lapstun Paul | 1609 |
| Howarth Richard P. | 1599 |
| Sun Jing | 1568 |
| Suzuki Takashi | 1565 |
| Koyama Jun | 1562 |
| Montojo Juan | 1550 |
| Liu Wei | 1549 |
| Seo Hanbyul | 1541 |
| Coster Daniel J. | 1501 |
| Smith Victoria | 1496 |
| Cherian George | 1492 |
| Whang Eugene Antony | 1482 |
| Zhang Hongyuan | 1481 |
| Zhang Yi | 1479 |
| Rohrbach Matthew Dean | 1473 |
| Chen Jian | 1459 |
| Chen Ying | 1454 |
| Ishikawa Muriel Y. | 1452 |
| Wang Jian | 1448 |
| Watanabe Colin K. | 1447 |
| Fan Shou-Shan | 1439 |
| Myhrvold Nathan P. | 1418 |
| De Iuliis Daniele | 1410 |
| Karaoguz Jeyhan | 1389 |
| Liu Jun | 1358 |
| Jorasch James A. | 1353 |
| Li Jun | 1334 |
| Hall David R. | 1332 |
| Li Xiang | 1327 |
| Sullivan Michael J. | 1307 |
| Damnjanovic Aleksandar | 1280 |
| Harris Jason L. | 1267 |
| Russell-Clarke Peter | 1263 |
| Wei Yongbin | 1258 |
| Forbes Leonard | 1250 |
| Sandhu Gurtej S. | 1249 |
| Zhou Yan | 1248 |
| Leuthardt Eric C. | 1237 |
| Seo Satoshi | 1228 |
| Liu Yang | 1225 |
| Kim Kijun | 1222 |
| Liu Yong | 1215 |
| Marinier Paul | 1207 |
| Wang Tao | 1204 |
| Nagata Satoshi | 1188 |
| Merlin Simone | 1186 |
| Reznicek Alexander | 1184 |
| Wang Xin | 1176 |
| Yi Yunjung | 1170 |
| Li Yan | 1169 |
| Baker Kevin P. | 1163 |
| Yue Henry | 1160 |
| Li Jian | 1156 |
| Wang Jing | 1155 |
| Resch Jason K. | 1122 |
| Liu Shan | 1120 |
| Malladi Durga Prasad | 1119 |